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Friday, June 14, 2024

CAR T Cell Therapy Market: A Dive Into The Emerging Market

CAR T cell therapies refer to the genetically modified T-cells that harness the capabilities of innate immunity to fight against a wide range of diseases, including cancer and chronic diseases. Cancer has been considered the leading cause of death across the globe. According to the World Health Organization, it is estimated that 27.5 million new cases of cancer will be detected by the end of 2040, exerting a burden on healthcare experts and pharmaceuticals to develop novel treatments. Notably, there are several therapies available, including chemotherapy, surgeries, and radiation therapies, that help to control the progression of cancer and prevent malignant cells from migrating throughout the body. However, the last diminution is still challenging for healthcare professionals to achieve.

To address the concern, pharmaceutical companies have developed CAR T therapy (a promising approach to eradicating tumor cells from the patient’s body with minimal side effects). The therapy involves modified T cells and monoclonal antibodies to fight against tumor cells inside the body. CAR T cell therapies are a new addition to anticancer interventions—they have shown significant results in the treatment of cancer patients. The tissue specificity and targeted approach of these therapies has revolutionized the treatment of cancer. Currently, CAR T cell therapy market players are increasing their efforts to discover molecular targets that can potentially treat cancer patients successfully. The ongoing research strengthens the CAR T cell therapies pipelines, which anticipates substantially growing the CAR T cell therapy market.  In this context, let’s read about market insight and future opportunities that are emerging in the market.

Current CAR T Cell Therapy Market Landscape

The CAR T cell therapy market landscape features more than 190 companies with technological expertise to develop therapies for treating oncological and non-oncological disorders. It is worth noting here that over 800 therapies based on the CAR T cells are in the clinical phase of drug development. Moreover, nearly 300 CAR T cell therapies that target oncological disorders are under the pre-clinical and discovery stage of drug development. Given by the increasing pipeline, CAR T cell therapy already holds a robust foothold in the pharmaceutical sector. Key players such as Kite Pharma and CARgen Therapeutics are reviving their CAR T therapies manufacturing process to enhance the development of more therapies targeting tumor cells. For instance, in January 2024, Kite Pharma received approval from the FDA for their advancement in the manufacturing process for Yescarta® (axicabtagene ciloleucel), eliminating the median turnaround time.

Emerging CAR T Cell Therapy Market: Advances and Opportunities

Initially, these CAR T cell-based therapies have been used to treat patients with hematological malignancies like lymphoma and leukemia. However, with ongoing technological advancements and growing interest in the CAR T cell therapy of key players, more applications are driving the market. Currently, researchers in this domain are navigating the potential ways to modify these therapies that can address the challenges associated with treating solid tumors, such as the immunosuppressive tumor microenvironments.

Furthermore, one of the significant challenges CAR T cell therapy faces is the reliability of patients’ T cell isolation and modification, which consume a lot of time and require massive investment. In order to address the limitation, pharmaceutical companies in the field are increasing their research and initiating investment in the manufacturing of off-the-shelf CAR T cell therapies. Moreover, researchers are focusing on redefining CAR designs using technological approaches to improve their efficacy, specificity, and safety profile. The approach will include an advanced co-stimulator domain, modification of CAR structure, and finding dual targeting CARs to reduce antigen escape and enhance tumor targeting potential.

Top Companies in the CAR T Cell Therapy Market

The growing interest of the industrial stakeholders in the CAR T cell therapy market can be attributed to the increasing partnerships for developing these therapies within the past few years. It is worth noting here that over 260 partnerships and strategic collaborations have been signed between the key players of the industry aiming to develop novel therapeutic treatments by harnessing the immunological cells of the body. In order to support the development of CAR T cell therapies, public and private sector investors have made a capital investment of over USD 32 billion within the past few years. Further, more than 10,000 patents associated with CAR T cell therapies have been granted / filed, indicating the continuous innovation in the market. Some of the notable examples of the key industrial leaders who are actively exploring new opportunities are listed below:

  • Alaunos Therapeutics
  • Autolus
  • Abelzeta Pharma
  • Bluebird Bio
  • Bristol Myers Squibb
  • Carsgen Therapeutics
  • Cellectis
  • Gilead Sciences
  • Innovative Cellular Therapeutics
  • Kuur Therapeutics
  • Noile-Immune Biotech
  • Novartis
  • Shanghai GeneChem
  • Sinobioway Cell Therapy
  • Takara Bio
  • Wellington Zhaotai Therapies

Current Milestones in the CAR T Cell Therapy Market

  • The current CAR T cell therapy market is witnessing several development activities that are anticipated to drive growth in this field. Examples of the key development activities that have taken place in the CAR T cell therapy market are listed below:
  • In February 2024, Astellas and Kelonia entered into a strategic agreement with the aim of developing CAR T cell therapy by combining the latter company’s ACCEL technology and iGPS system.
  • In January 2024, China approved Intaicabtagene Autoleucel (next-generation CD19 targeting CAR T cell therapy) to treat patients of relapsed or refractory B cell acute lymphoblastic leukemia.
  • In October 2023, the Central Drug Standard Control Organization gave approval to NexCAR19 (next-generation CAR T cell therapy) to treat patients with advanced lymphoma or leukemia.

CAR T Cell Therapy:  A Bright Future Ahead

Overall, CAR T cell therapy brings a revolution in oncology by offering several tailored treatments on the basis of the patient physiological profile. The approach of personalized treatment using CAR T cell therapy involves genetically modified patients’ T cells that have the potential to bind to specific tumor antigens. Considering the potential of CAR T cell therapies to treat cancer patients, several key players in the industry are driving research to develop innovative therapies that can address rare disease indications. In the future, as the sheer number of individuals suffering from cancer continues, pharmaceutical companies continue to develop cell therapies, which are anticipated to drive the CAR T cell therapy market at a substantial rate.

About Roots Analysis

Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists, and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights. All reports provided by us are structured in a way that enables the reader to develop a thorough perspective on the given subject. Apart from writing reports on identified areas, we provide bespoke research / consulting services dedicated to serving our clients in the best possible way.

Uneeb Khan
Uneeb Khan
This is Uneeb Khan, have 4 years of experience in the websites field. Uneeb Khan is the premier and most trustworthy informer for technology, telecom, business, auto news, games review in World.

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